This site incorporates brief specifics of bortezomib and a collection of backlinks to a lot more information regarding the usage of this drug, exploration success, and ongoing scientific trials.

levoketoconazole will improve the stage or influence of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.

You will find reviews of several lethal results from bortezomib overdose. In the event the affected individual ordeals an overdose, shut monitoring while in the ICU is recommended. Aggressive hydration and upkeep of normal entire body temperature are vital.

you should know that bortezomib may cause dizziness, lightheadedness, and fainting after you get up much too promptly from a lying position. This is much more prevalent in people who have fainted in the past, people who find themselves dehydrated, and people who are getting remedies that decrease blood pressure.

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larotrectinib will enhance the degree or influence of bortezomib Ritobegron HCl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unfamiliar.

cannabidiol will increase the stage or effect of bortezomib by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Watch Closely. Contemplate decreasing the dose of delicate CYP2C19 substrates, as clinically proper, when coadministered with cannabidiol.

Remember to see your health treatment professional To find out more about your specific medical situation and the use of this drug.

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Diabetic issues mellitus: Individuals getting oral hypoglycemic agents are in danger for building hypo Retene or hyperglycemia when handled with bortezomib; hence, the blood sugars need careful monitoring.

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mitotane decreases amounts of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Mitotane is a strong inducer of cytochrome P-4503A4; observe when coadministered with CYP3A4 substrates for doable dosage changes.

Bortezomib therapy requires a collaborative exertion from your interprofessional Health care team. The drug might cause hypotension, and also the nurse ought to Verify the BP routinely. Nursing personnel should report any signs of adverse functions to the attending clinician right away and Look at With all the pharmacist. If you'll find any questions about the drug, a person ought to consult with With all the pharmacist to start with.